Clinical trial website struggles to serve as research data hub

Clinical trial data as a public good.

KNOWLEDGE OF THE BENEFITS AND RISKS OF PRESCRIPtion drugs is based mainly on published reports of clinical trials, yet the medical literature may present an incomplete and potentially biased sample of clinical trials. Trials with positive results generally are published more frequently than studies that conclude that a new drug poses greater risks or is no more effective than standard therapy o...

Target hub proteins serve as master regulators of development in yeast.

To understand the organization of the transcriptional networks that govern cell differentiation, we have investigated the transcriptional circuitry controlling pseudohyphal development in Saccharomyces cerevisiae. The binding targets of Ste12, Tec1, Sok2, Phd1, Mga1, and Flo8 were globally mapped across the yeast genome. The factors and their targets form a complex binding network, containing p...

Communicating clinical trial results to research participants.

BACKGROUND Communicating clinical trial results to research participants is seldom accomplished in a timely or an effective manner. OBJECTIVE To evaluate the effectiveness of a plan to communicate results in an industry-sponsored randomized controlled trial for Huntington disease. DESIGN, SETTING, AND PARTICIPANTS Postal survey to research participants at 28 of 41 research sites (including ...

From Laboratory Research to a Clinical Trial

Objective: This is a translational science article that discusses copper alloys as antimicrobial environmental surfaces. Bacteria die when they come in contact with copper alloys in laboratory tests. Components made of copper alloys were also found to be efficacious in a clinical trial. Background: There are indications that bacteria found on frequently touched environmental surfaces play a rol...

Introduction: evaluating clinical trial data from schizophrenia research.